Leveraging our proprietary AceMouse™ antibody discovery platform, we have delivered over twenty fully validated therapeutic molecules for global partners, spanning human monoclonal antibodies (mAbs), common light chain bispecifics (including CD3 engagers), antibody cores for ADCs, and CAR constructs. >75% of these programs have advanced to preclinical development stages (PK/PD/toxicity/CMC), demonstrating robust platform translatability. We possess unique expertise in drugging challenging targets, including conserved proteins and complex membrane receptors like GPCRs – translating biological insights into clinically developable candidates.
· Three distinct fully human antibody mouse platforms address diverse development needs for monoclonal antibodies (mAbs), bispecifics, and nanobodies, enabling comprehensive support for all fully human antibody-based therapeutics.
· Unparalleled humanization depth in both heavy- and light-chain variable region gene clusters generates maximal human V(D)J recombination diversity to capture rare epitopes with clinical relevance.
· Site-specific genomic recombination via homologous replacement preserves native murine antibody regulatory elements, ensuring physiological antibody production and GLP-compliant PK profiles.
· Multi-strain compatibility (BALB/c, CD1, SJL) enables immunization optimization across disease models while maintaining wild-type-level antigen-specific responses, validated in oncology, immunology, and CNS programs.
In the early stages of drug development, we adhere to the principle of "quick win, fast fail." During the early discovery phase, we strive to mitigate potential risks as much as possible, such as specificity risks, efficacy and toxicology risks, stability risks, and process development risks. By conducting more in-depth research, enhancing exploratory depth, and performing thorough analysis and prediction at this stage, we aim to avoid greater wastage of resources and time in later development phases.
AceMab collaborates closely with Taichu group —TaiChu Bio (Pre-Clinical Research CRO ) and Tarlead Biologics (Biologics Development and Manufacturing CDMO ) —to thoroughly consider risks early on and conduct comprehensive validation work. Ultimately, we are committed to advancing the most promising molecules to the market, contributing to human health and well-being.
AceMab places exceptional emphasis on project management, with all team members—from the founders to the project managers—holding professional PMP certification issued by a UK-based project management training institution. Dr. Li Jianliang, the founder, believes that the most easily overlooked cost for enterprises is project management cost, and the most easily overlooked benefit is management efficiency. Therefore, it is essential for AceMab’s internal scientists and project management team to receive professional training in management. Throughout project execution, we welcome valuable feedback from our clients, as it enables us to continuously improve and advance. This has always been our original intention and service commitment.