Based on years of experience in cell line construction, the cell line development team can conduct molecular construction and monoclonal screening of various antibodies, fusion proteins and sufficient proteins. For bispecific antibodies or multiantibodies with complex molecular structures, a stable and efficient platform development process has been optimized.

The cell line development experiment has advanced cell line screening equipment such as 7500 QPCR instrument, Vi cell Blu cell viability analyzer, multiple countstars, multiple cell metric single cell imaging instruments, multiple Gator Prime non labeled biological analyzer instruments, high-throughput biochemical analyzer, etc. It can undertake more than 5 complete cell line construction and monoclonal screening projects each year, and can also provide cell line construction or screening services at different stages, Provide comprehensive service to customers.

Service scope

Overall case presentation

During the period of 2020 to 2022, the expression level of bispecific antibodies in the platform was observed.

1. Service Cases

1.1 Background

Development of dual antibody project cell lines

1.2 Challenges

Timeline Urgent Development of Dual Antibody Molecular Processes

1.3 Solution/Results

Optimization of different transfection ratios using stable expression

Adopt "relay race style development"

Simultaneous evaluation of Fed-batch and stability during the monoclonal screening stage