1. Responsible for process transfer and amplification of mRNA products;

2. Optimize and transfer technology for plasmid linearization, in vitro mRNA transcription process, and mRNA purification process; 3. Assist in implementing process transfer, develop mRNA production strategies, and complete process amplification confirmation in our company's GMP production workshop;

4. Collaborate with the analysis team to establish mRNA analysis and detection methods;

5. Responsible for the construction of mRNA process platform, including personnel training, equipment selection and maintenance, material management, SOP writing and review, etc;

6. Responsible for promoting and efficiently completing project related work, drafting and preparing relevant SOP and testing records in accordance with the requirements of FDA, ICH, and Chinese Pharmacopoeia, and preparing normative documents and application materials, such as technical documents, plans, and reports;

7. Responsible for the use, cleaning, maintenance, calibration, confirmation/validation of relevant instruments and equipment;

8. Complete other related tasks arranged by the company.

1. Majors in biology, chemistry, pharmacy, and related fields, preferably in molecular biology, with a bachelor's degree or above;

2. At least 2 years of experience in molecular biology research;

3. Experience in GMP production, with audit experience preferred;

4. Experience in in vitro mRNA transcription, familiar with IVT related equipment and processes, and experience in process development is preferred;

5. Have a certain understanding of mRNA purification;

6. Can adapt to a fast-paced atmosphere and has good pressure resistance.

1. Responsible for the research and development of mRNA-LNP, including but not limited to information collection and organization, experimental design, execution, recording, data analysis, etc; Regularly report on experiments and work progress;

2. Independently or leading a team to complete projects related to the research and development of nucleic acid LNP formulations and process development, including prescription process transfer and process amplification of LNP;

3. Responsible for the research and development of the LNP packaging process of mRNA therapeutic drugs, conducting technical research and designing process plans for cutting-edge fields, solving technical problems encountered in the delivery of mRNA packaging, participating in the quality inspection of lipid nanoparticle (LNP), and assisting in determining quality inspection items, methods and standards;

4. Cooperate with personnel from other departments based on project progress and provide LNP related technical support;

5. Assist the project leader in summarizing and writing relevant materials;

6. Effectively implement laboratory standards, have a sense of sterile operation, and ensure the sterile safety of raw materials, auxiliary materials, and operating processes;

7. Complete other related tasks arranged by the company.

1. Bachelor's degree or above in chemistry, biology, medicine, or pharmaceutical related fields;

2. Possess relevant chemical or biological experimental skills; Experience in research related to nucleic acid drug delivery;

3. Experience in GMP production, with audit experience preferred;

4. Proficient in experimental methods related to nanoparticles and drug delivery systems, familiar with particle characterization, encapsulation rate detection, and release performance related technologies and methods.

1. Responsible for designing and optimizing novel structures of small molecules suitable for ADC through literature review, analysis, and experimental research, including the design of small molecules, optimization of drug properties, structure-activity relationship research, screening and evaluation, etc;

2. Responsible for planning the progress of related ADC small molecule drug research and development projects and outsourcing drug research and development projects, and promoting project progress;

3. Participate in the company's ADC small molecule research and development decisions, conduct research in the research field, complete the selection and determination of research directions, and design solutions;

4. Optimize the structure of small molecule compounds and conduct necessary research on their medicinal properties; Collaborate with colleagues in synthesis and pharmacological pharmacokinetics to conduct in-depth research;

5. Responsible for writing project progress reports and communicating and reporting project progress;

6. Complete the evaluation of the synthesis, chemical stability and metabolic stability of small molecule drugs.

1. Master's or doctor's degree in organic chemistry, medicinal chemistry, biochemistry and other related majors;

2. At least 2 years of work experience in small molecule drug design and development, including compound design, route design, compound synthesis, patent writing, etc; Or a recent PhD;

3. Understand the basic knowledge of small molecule efficacy, pharmacokinetics, and toxicology;

4. Experience in small molecule drugs from drug design to PCC and IND application is preferred;

5. Have a diligent and studious work attitude, be able to proactively discover, analyze, and solve problems that arise in work, and possess excellent experimental design and optimization skills;

6. Excellent communication and execution skills, strong sense of responsibility and teamwork spirit.

1. Report to the company leader, fully responsible for the research and development of ADC antibody conjugated drugs and team management work;

2. As the department head, responsible for screening antibodies and small molecule drug coupling molecules, and developing coupling pilot processes. Guide the selection of possible small molecule drugs and linkers, guide drug synthesis, and solve key technical problems in the project;

3. Continuously track literature, patents, and conferences in areas of concern to the company, and track the progress of new compounds in professional companies;

4. Conduct necessary benchmarking analysis and patent due diligence on candidate small molecule drugs and linkers;

5. Manage project progress and timeline, coordinate with other departments to advance project completion.

1. Doctor of organic chemistry, medicinal chemistry or related majors, with more than 5 years of related research or work experience; Or a master's degree plus 7 years of relevant research and development work; Familiar with the development laws and quality requirements at different stages of new drug development;

2. Rich ability in the synthesis and development of small molecule drugs, proficient in small molecule design, synthesis, process, and quality control, able to efficiently analyze and solve problems;

3. Familiar with the small molecule research and development path in the ADC development process is preferred;

4. Proactive and dedicated in work, down-to-earth and conscientious, with a strong sense of responsibility, and excellent innovation and pressure resistance ability;

5. Excellent communication and execution skills, good team management and collaborative spirit.

1. Responsible for designing and executing the synthesis, purification, and analysis of small nucleic acid drugs;

2. Responsible for designing and operating high-throughput solid-state synthesis, purification, and analysis, as well as synthesizing various chemically modified oligonucleotides;

3. Responsible for the improvement and development of oligonucleotide synthesis and purification processes, as well as analytical methods;

4. Responsible for operating and maintaining relevant experimental platforms, and able to provide reasonable solutions when encountering problems;

5. Responsible for coordinating and tracking work within the company to ensure the smooth progress of the project.

1. Major in organic chemistry, medicinal chemistry, biochemistry and other related majors, with a master's degree of at least 3 years or a doctor's degree, and some experience in synthesis, purification and analysis;

2. Familiar with and proficient in molecular biology related technologies, proficient in cell culture, stable cell line construction, Western Blot, ELISA, confocal analysis, FACS, sequence alignment analysis, etc;

3. Have a diligent and studious work attitude, be able to proactively discover, analyze, and solve problems that arise in work, and possess excellent experimental design and optimization skills;

4. Excellent communication and execution skills, strong sense of responsibility and teamwork spirit.

1. Build and organize a small nucleic acid research and development team and platform, lead the team to promote small nucleic acid projects and complete corresponding milestones;

2. Lead the design, modification, and optimization of small nucleic acids in different drug research and development fields;

3. Interpret and understand the activity data of small nucleic acid drugs in various biological systems, and identify and optimize lead compound to pre clinical candidate drugs;

4. Provide technical support for nucleic acid drug design, modification, synthesis, delivery technology, CMC, organize and implement cell, analytical testing, animal testing, raw materials, formulations, non clinical trials, and related research trials of the project, and promote project completion;

5. Lead a team to efficiently solve technical problems in the development of nucleic acid drugs.

1. Doctor degree or above, major in organic chemistry, medicinal chemistry, etc. Proficient in small nucleic acid modification and synthesis, with experience in building small nucleic acid platforms from 0 to 1 is preferred;

2. Familiar with small nucleic acid delivery technology, proficient in small nucleic acid modification, synthesis, and purification, with relevant synthesis experience and project management experience in preclinical research and development;

3. Familiar with the screening and evaluation experiments of small nucleic acid drugs;

4. Have unique insights into nucleosides, nucleotides, phosphoramide monomers and oligonucleotide synthesis reactions related to small nucleic acids (such as antisense oligonucleotide and siRNAs);

5. Experience in preclinical research and development of small nucleic acid and team management is preferred.

1. Coordinate company resources according to project arrangements to ensure the normal progress of the project.

2. Develop a node assurance plan and implement process execution audits. Track project progress, control and manage project plans, progress, milestones, and costs.

3. Organize project meetings, regularly report project progress, and coordinate to solve problems that arise during project operation.

4. Monitor project progress, identify potential risks, and provide timely warnings when important time points are delayed.

5. Organize problem analysis and work with the business team to develop improvement and prevention plans.

6. Do a good job in project document management to ensure accurate and timely transmission and feedback of various documents, materials, data, and other information.

7. Coordinate communication and collaboration among project members and departments, integrate resources from various links, and ensure the achievement and completion of project goals.

1. Bachelor's degree or above, major in biology or medicine is preferred;

2. Master's degree of at least 5 years or bachelor's degree of at least 7 years of relevant management work experience, holding a PMP certificate is preferred; 3. Familiar with the project management system and system delivery process, with experience in drug research and development project management preferred, familiar with the drug research and development process;

4. Strong project driving and execution abilities;

5. Excellent cross team collaboration ability, proactive and good at communication; Strong logical thinking ability, good at analyzing and solving problems;

6. Strong communication and presentation skills, able to independently face various biopharmaceutical customer groups.

1. Responsible for daily animal husbandry work in the animal room (including feeding, changing water, changing cages, and cleaning);

2. Sterilization work: According to the requirements of standard operating procedures, complete the cleaning, hygiene, and disinfection of the area under one's responsibility; 3. Assist each group in conducting relevant operating procedures for the experiment, and complete the relevant record forms according to regulations;

4. Responsible for the reproduction of experimental animals and assisting in the identification of mouse genotypes;

5. Assist in the immune work of experimental animals;

6. Update database records and animal experiment related reports, communicate and provide timely feedback when problems are found, analyze problems, and summarize and report;

7. Complete other tasks assigned by superiors.

1. College/undergraduate degree in animal science related majors;

2. At least 2 years of working experience in SPF grade animal rooms;

3. Experience in injecting experimental animal drugs is a plus;

4. Encourage those who have a strong interest in raising experimental animals to apply.

1. As a reserve SD, assist SD in conducting experimental research work and fulfill their job responsibilities and SOP requirements;

2. Assist in organizing the test preparation meeting, participate in the discussion and preparation of the commissioning party's test projects;

3. Implement the research plan according to the experimental plan, verify the research process and data;

4. Timely report and assist in handling deviations and anomalies during the experiment;

5. Assist SD in summarizing the research report and organizing data materials;

6. Track updates on relevant technical guidelines (FDA, OECD, SFDA, and ICH), participate in or organize training.

1. Bachelor's degree or above in medicine, biology, medicine, or analytical related fields;

2. At least 2 years of toxicological research experience; Familiar with GLP specifications and requirements in China, the United States, and OECD. Familiar with one of the following fields is preferred: general toxicology, safety pharmacology, genetic toxicology, reproductive toxicology, immune toxicology;

3. Good writing skills and interpersonal communication communication skills. Good English reading and writing skills are preferred. Have a team spirit. Strong learning and problem-solving skills. Familiar with LIMS software users are preferred (such as Provantis).

1. Responsible for completing the toxicological test design according to the test requirements, grasping the scientific nature of the test, and issuing the test plan;

2. Responsible for controlling the progress of toxicological tests and ensuring the quality of the tests;

3. Responsible for communicating with the commissioning party about the progress of the experiment;

4. Responsible for communicating with relevant departments for experimental arrangements;

5. Responsible for interpreting toxicological test data and issuing reports;

6. Responsible for assisting QA in completing the inspection of the test by the inspection agency.

1. Master's degree or above in pharmacy, toxicology, pharmacology, traditional Chinese medicine, or related fields;

2. At least 3 years of work experience as a toxicology specialist in GLP laboratories;

3. College English Level 6; Familiar with the advantis system is preferred.