Rich repertoire of fully human antibody variable region:
Complete functional human Heavy Vs loci substitution in situ;
Complete functional human Kappa Vs loci substitution in situ;
Complete functional human Lambda Vs loci substitution in situ.
Normal B cell development comparable to wildtype littermate.
Complete absence of endogenous mouse Heavy, Kappa and Lambda gene segments.
High affinity (subnanomolar to picomolar) antibodies straight from the mice.